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Related Experiment Videos

Intracranial plasma cell granuloma.

I H Tekkök1, E C Ventureyra, C L Jimenez

  • 1Bayindir Medical Center, Ankara, Turkey.

Brain Tumor Pathology
|April 20, 2001
PubMed
Summary
This summary is machine-generated.

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Plasma cell granulomas (PCGs) are rare benign brain tumors. This study details a rare intracranial PCG case, highlighting its unique histological impact on adjacent brain tissue.

Area of Science:

  • Neurology
  • Pathology
  • Oncology

Background:

  • Plasma cell granulomas (PCGs) are benign inflammatory masses, typically found in the lungs.
  • Intracranial PCGs are exceptionally rare, with limited documented cases.

Observation:

  • A rare case of a dural-based right frontal mass in an 11-year-old girl presenting with seizures.
  • The tumor extended towards the sagittal sinus and falx, requiring total excision with surrounding dura and limited cortical resection.
  • Histopathological analysis confirmed intracranial plasma cell granuloma through immunohistochemistry and electron microscopy.

Findings:

  • This is the third reported case of intracranial PCG, providing new insights into its effects on adjacent cerebral tissue.
  • While PCGs are well-defined, associated lymphoplasmocytic inflammation, neuronal loss, and reactive gliosis were observed in the neighboring cortex.

Related Experiment Videos

  • A novel finding of disturbed cortical lamination in the adjacent brain tissue was identified.

    • Implications:

    • This case expands the understanding of rare intracranial tumors and their pathological impact.
    • Highlights the importance of thorough histopathological examination for diagnosing rare intracranial lesions.
    • Suggests PCGs can induce unique histological changes in adjacent brain tissue, including cortical lamination abnormalities.