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Intracranial plasma cell granuloma.
I H Tekkök1, E C Ventureyra, C L Jimenez
1Bayindir Medical Center, Ankara, Turkey.
Brain Tumor Pathology
|April 20, 2001
Summary
Plasma cell granulomas (PCGs) are rare benign brain tumors. This study details a rare intracranial PCG case, highlighting its unique histological impact on adjacent brain tissue.
Area of Science:
- Neurology
- Pathology
- Oncology
Background:
- Plasma cell granulomas (PCGs) are benign inflammatory masses, typically found in the lungs.
- Intracranial PCGs are exceptionally rare, with limited documented cases.
Observation:
- A rare case of a dural-based right frontal mass in an 11-year-old girl presenting with seizures.
- The tumor extended towards the sagittal sinus and falx, requiring total excision with surrounding dura and limited cortical resection.
- Histopathological analysis confirmed intracranial plasma cell granuloma through immunohistochemistry and electron microscopy.
Findings:
- This is the third reported case of intracranial PCG, providing new insights into its effects on adjacent cerebral tissue.
- While PCGs are well-defined, associated lymphoplasmocytic inflammation, neuronal loss, and reactive gliosis were observed in the neighboring cortex.
- A novel finding of disturbed cortical lamination in the adjacent brain tissue was identified.
Implications:
- This case expands the understanding of rare intracranial tumors and their pathological impact.
- Highlights the importance of thorough histopathological examination for diagnosing rare intracranial lesions.
- Suggests PCGs can induce unique histological changes in adjacent brain tissue, including cortical lamination abnormalities.