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The relation between glutamine and the immunodepression observed in exercise.

L M Castell1, E A Newsholme

  • 1University Department of Biochemistry, Oxford, United Kingdom.

Amino Acids
|April 20, 2001
PubMed
Summary

Supplementing with glutamine after exhaustive exercise may reduce infection risk. This amino acid fuels immune cells, which are depleted by intense physical activity, potentially lowering upper respiratory tract infection incidence.

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Area of Science:

  • Exercise immunology
  • Nutritional science

Background:

  • Glutamine is the most abundant amino acid.
  • It serves as a crucial fuel source for immune cells.
  • Prolonged, exhaustive exercise depletes plasma glutamine levels and impairs immune cell function.

Purpose of the Study:

  • To investigate the role of glutamine supplementation in mitigating exercise-induced immunodepression.
  • To assess the impact of glutamine provision on infection rates following intensive exercise.

Main Methods:

  • Review of existing clinical data and studies on glutamine's effects.
  • Analysis of immune cell function and plasma glutamine concentrations post-exercise.
  • Evaluation of infection incidence in athletes receiving glutamine supplementation.

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Main Results:

  • Glutamine supplementation has shown benefits in various clinical settings.
  • Provision of glutamine post-exercise has been linked to a reduced incidence of infections.
  • Specifically, a decrease in upper respiratory tract infections was observed.

Conclusions:

  • Glutamine plays a vital role in immune system fuel and function.
  • Supplementation may help counteract exercise-induced immune suppression.
  • Further research is needed to precisely establish glutamine's effect on exercise-related immunodepression.