Managing the menopause: phyto-oestrogens or hormone replacement therapy?
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Updated: Oct 8, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Abstract:
Menopause is a natural event, and understandably many women would like to take a natural therapy rather than a drug for managing their menopause symptoms as well as preventing the long-term sequelae of oestrogen deficiency. In this respect phyto-oestrogens show a lot of promise. However, at this point in time clinical data are inconclusive. There are some data supporting the contention that isoflavones improve hot flushes; however, there are also negative studies. Soy protein has been shown to lower cholesterol, and isoflavones improve arterial compliance. Clinical studies suggest that isoflavones have little impact on menopause-induced bone loss.
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