Related Experiment Videos
Ototoxicity with children caused by streptomycin
Insights
Streptomycin sulphate treatment for childhood pulmonary tuberculosis can cause hearing loss. Audiological examinations revealed ototoxic lesions in 36% of children, impacting the vestibular system and/or the organ of Corti.
Area of Science:
- Ototoxicology
- Pediatric Pulmonology
- Audiology
Background:
- Pulmonary tuberculosis is a significant childhood illness.
- Streptomycin sulphate is a common antibiotic treatment for tuberculosis.
- Ototoxicity is a known side effect of certain antibiotics.
Purpose of the Study:
- To assess the incidence and nature of ototoxic lesions in children treated with streptomycin sulphate for pulmonary tuberculosis.
- To evaluate the audiological effects of streptomycin sulphate in a pediatric population.
Main Methods:
- Audiological examinations were conducted on 975 children treated for pulmonary tuberculosis.
- Ototoxic lesions were identified and categorized based on affected auditory structures.
Main Results:
- 36% of children exhibited ototoxic lesions.
- Vestibular labyrinth damage occurred in 24% of cases.
- Damage to both vestibular and cochlear systems (organ of Corti) was observed in 8% of children.
- Isolated organ of Corti damage was present in 4% of children.
Conclusions:
- Streptomycin sulphate treatment is associated with a significant risk of ototoxicity in children with pulmonary tuberculosis.
- The vestibular system is frequently affected, with combined cochlear and vestibular damage also being notable.
- Regular audiological monitoring is crucial for children receiving streptomycin sulphate therapy.
Abstract:
In the hospital for pulmonary tuberculosis in children, a group of 975 children treated with streptomycin sulphate was audiologically examined and in 36% of children ototoxic lesions were defined. From these, in 24% the damage affected only the vestibular labyrinth, in 8% both the vestibular labyrinth and the organ of Corti and in 4% the organ of Corti alone.