Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

APAP, a sequence-pattern recognition approach identifies substance P as a potential apoptotic peptide.

G del Rio1, S Castro-Obregon, R Rao

  • 1Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945-1400, USA.

FEBS Letters
|April 20, 2001
PubMed
Summary

Researchers developed a computational method to identify pro-apoptotic peptides (PAPs) for cancer chemotherapy. This approach aids in discovering new peptide drugs that induce apoptosis in targeted cancer cells.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline.

AJNR. American journal of neuroradiology·2015
Same author

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

Cell death and differentiation·2014
Same author

Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-β peptide of amyloid precursor protein.

Neuroscience·2011
Same author

Aerosol features retrieved from solar aureole data: a simulation study concerning a turbid atmosphere.

Applied optics·2010
Same author

Hybrid x-ray/optical luminescence imaging: characterization of experimental conditions.

Medical physics·2010
Same author

Corticosteroid - induced avascular necrosis of head of femur in a patient with pemphigus vulgaris.

Indian journal of dermatology, venereology and leprology·2010

Area of Science:

  • Biochemistry
  • Computational Biology
  • Oncology

Background:

  • Novel cancer chemotherapeutic strategies are needed.
  • Pro-apoptotic peptides (PAPs) offer a targeted approach to induce cancer cell death.
  • Existing methods for identifying PAPs are limited.

Purpose of the Study:

  • To develop a computational method for identifying potential pro-apoptotic peptides.
  • To improve the efficacy of peptide-based cancer chemotherapy.

Main Methods:

  • Developed the Approach for Predicting Potential Apoptotic Peptides (APAP) computational tool.
  • APAP predicts peptide helical content, hydrophobic moment, and isoelectric point.
  • Experimentally validated identified peptides, including substance P.

Related Experiment Videos

Main Results:

  • APAP successfully identified short PAPs.
  • Substance P was identified as a PAP and experimentally confirmed as pro-apoptotic.
  • Identified PAPs demonstrated toxicity against bacteria and mitochondria, but not extracellular mammalian cells.

Conclusions:

  • The APAP computational method is effective for detecting and improving pro-apoptotic peptides.
  • This approach has the potential to advance peptide-based cancer chemotherapy.
  • Further research can optimize PAPs for targeted cancer treatment.