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Involvement of disregulated c-myc but not c-sis/PDGF in atypical and anaplastic meningiomas

G Nagashima1, M Aoyagi, S Yamamoto

  • 1Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan. goro-n@po1.dti2.ne.jp

Clinical Neurology and Neurosurgery
|April 20, 2001
PubMed

Insights

This study found that c-myc expression is linked to meningioma malignancy, unlike c-sis/PDGF. C-myc protein and mRNA were detected in higher-grade meningiomas, correlating with proliferation markers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Neurosurgery

Background:

  • Meningiomas are tumors arising from the meninges.
  • Understanding molecular markers associated with meningioma grade is crucial for diagnosis and treatment.

Purpose of the Study:

  • To investigate the expression of c-myc and c-sis/platelet-derived growth factor (PDGF) in meningiomas of varying grades.
  • To determine the correlation between these markers and tumor malignancy.

Main Methods:

  • Examined 20 meningioma cases (10 benign, 5 atypical, 5 anaplastic).
  • Utilized immunohistochemistry and in situ hybridization to detect c-myc and c-sis/PDGF mRNA and protein.
  • Assessed Ki-67 proliferative indices.

Main Results:

  • C-myc protein and mRNA were present in all atypical and anaplastic meningiomas, but absent in most benign cases.
  • PDGF-BB protein and c-sis mRNA were found in over 80% of all meningioma grades.
  • C-myc immunopositivity correlated with Ki-67 proliferation indices.

Conclusions:

  • C-myc expression is associated with meningioma malignancy.
  • C-sis/PDGF does not appear to be a reliable indicator of meningioma grade.
  • C-myc may serve as a potential biomarker for meningioma progression.

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