Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The human Y chromosome: function, evolution and disease.

L Quintana-Murci1, C Krausz, K McElreavey

  • 1Unité d'Immunogénétique Humaine, Institut Nationale de la Santé et de la Recherche Médicale (INSERM) E0021, Institut Pasteur, 25-28 rue du Dr. Roux, 75724 Cedex 15, Paris, France. quintana@pasteur.fr

Forensic Science International
|April 20, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pubertal induction and transition to adult sex hormone replacement in patients with congenital pituitary or gonadal reproductive hormone deficiency: an Endo-ERN clinical practice guideline.

European journal of endocrinology·2022
Same author

Safety issues in semen banks during the COVID-19 pandemic: data from a European survey.

Journal of endocrinological investigation·2022
Same author

Management of male factor infertility: position statement from the Italian Society of Andrology and Sexual Medicine (SIAMS) : Endorsing Organization: Italian Society of Embryology, Reproduction, and Research (SIERR).

Journal of endocrinological investigation·2022
Same author

A de novo paradigm for male infertility.

Nature communications·2022
Same author

The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: Scrotal ultrasound reference ranges and associations with clinical, seminal, and biochemical characteristics.

Andrology·2020
Same author

Corrigendum. Sequencing of a 'mouse azoospermia' gene panel in azoospermic men: identification of RNF212 and STAG3 mutations as novel genetic causes of meiotic arrest.

Human reproduction (Oxford, England)·2020
Same journal

Technical note: Development of a UHPLC-MS/MS method for the analysis of hCG and IGF-I from dried blood spots: A preliminary study.

Forensic science international·2026
Same journal

A novel and robust deep learning model for sibling firearm matching.

Forensic science international·2026
Same journal

Changes in C-reactive protein levels over time in high-temperature environments using postmortem blood.

Forensic science international·2026
Same journal

Insights from the first synthetic cannabinoid clandestine lab dismantled in Brazil.

Forensic science international·2026
Same journal

Determination of the new psychoactive substances MDMB-4en-PINACA, ADB-BUTINACA and some of their metabolites in blood and urine using DLLE-LC-MS/MS: application to real forensic case samples.

Forensic science international·2026
Same journal

The revolver halo as a forensic marker: Raman spectroscopic evidence of primer-driven gunshot residue deposition.

Forensic science international·2026
See all related articles

The human Y chromosome is crucial for tracing human evolution and population history. While often assumed to be neutral, selection may influence Y chromosome patterns, especially concerning male fertility.

Area of Science:

  • Human Genetics
  • Population Genetics
  • Evolutionary Biology

Background:

  • The human Y chromosome is paternally inherited and largely does not recombine during male meiosis.
  • These characteristics make it a valuable genetic marker for studying human evolution, migrations, and forensic applications.
  • Current research often assumes Y chromosome markers are selectively neutral.

Purpose of the Study:

  • To review the genes, biological functions, and population history applications of the human Y chromosome.
  • To examine the role of selection acting on the Y chromosome in the context of human population history and disease.
  • To discuss how selection may influence Y chromosome haplotype distribution and challenge existing assumptions.

Main Methods:

  • Review of experimental and statistical analyses on Y chromosome selection.

Related Experiment Videos

  • Analysis of Y chromosome genes and biological functions.
  • Examination of Y chromosome use in population genetics and forensic studies.

    • Main Results:

    • Recent analyses suggest both positive and negative selection act on the Y chromosome.
    • Selection may influence Y chromosome haplotype distribution, though current effects on overall distribution appear minimal.
    • The assumption of Y chromosome marker neutrality may be challenged, particularly concerning male fitness traits like fertility.

    Conclusions:

    • The human Y chromosome is a powerful tool for understanding human history and population dynamics.
    • While selection's impact is currently considered minimal, its role in male fitness warrants further investigation.
    • Future studies should consider potential selective pressures when using Y chromosome data.