Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interactions between endothelial cells and HIV-1.

F Bussolino1, S Mitola, G Serini

  • 1Department of Genetics, Biology and Biochemistry, Institute for Cancer Research and Treatment, School of Medicine, University of Torino, s.p. 142, Km. 395, 10060 Candiolo, Torino, Italy. fbussolino@irce.unito.it

The International Journal of Biochemistry & Cell Biology
|April 20, 2001
PubMed
Summary

Human immunodeficiency virus (HIV)-1 infection profoundly alters endothelial cells (EC), impacting immune responses and contributing to HIV-associated vascular diseases like Kaposi's sarcoma. Understanding EC activation is key to addressing these complications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epidemiological and molecular characterization of HBV and HCV infections in HIV-1-infected inmate population in Italy: a 2017-2019 multicenter cross-sectional study.

Scientific reports·2023
Same author

Consensus clustering methodology to improve molecular stratification of non-small cell lung cancer.

Scientific reports·2023
Same author

TFEB inhibition induces melanoma shut-down by blocking the cell cycle and rewiring metabolism.

Cell death & disease·2023
Same author

Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations.

Biomechanics and modeling in mechanobiology·2023
Same author

Role of VEGFs in metabolic disorders.

Angiogenesis·2019
Same author

D-dimer levels and risk of recurrence following provoked venous thromboembolism: findings from the RIETE registry.

Journal of internal medicine·2019

Area of Science:

  • Immunology
  • Virology
  • Cell Biology

Background:

  • Endothelial cells (EC) are crucial participants in inflammatory and immune responses.
  • Human immunodeficiency virus (HIV)-1 significantly alters EC function and can infect EC, establishing a viral reservoir.
  • EC dysfunction is implicated in HIV-associated vasculopathy and neurological damage.

Purpose of the Study:

  • To discuss the biological and molecular activation of EC during HIV-1 infection.
  • To elucidate the role of EC alterations in the pathogenesis of HIV-1 associated vascular diseases.

Main Methods:

  • Review of existing literature on EC biology in the context of HIV-1 infection.
  • Analysis of molecular mechanisms underlying EC activation and dysfunction.

Related Experiment Videos

Main Results:

  • HIV-1 infection alters EC adhesive properties, affecting leukocyte traffic and immune surveillance.
  • EC damage contributes to blood-brain barrier perturbation and neurodegeneration.
  • Altered EC functions are central to the development of acquired immunodeficiency syndrome (AIDS)-related vasculopathy and Kaposi's sarcoma.

Conclusions:

  • HIV-1 infection profoundly impacts EC, serving as a basis for understanding associated vascular pathologies.
  • Targeting EC activation pathways may offer therapeutic strategies for HIV-1 associated vascular complications.