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Adaptive axonal remodeling in the midbrain auditory space map.

W M DeBello1, D E Feldman, E I Knudsen

  • 1Department of Neurobiology, Sherman Fairchild Sciences Building, Stanford University School of Medicine, Stanford, California 94305-5125, USA. wmdebello@ucdavis.edu

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|April 20, 2001
PubMed
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Barn owls adapt their auditory space map when exposed to visual displacement. This functional plasticity involves axonal remodeling, with prism experience promoting sprouting and new connections in the brain.

Area of Science:

  • Neuroscience
  • Neurobiology
  • Sensory processing

Background:

  • The external nucleus of the inferior colliculus (ICX) in barn owls exhibits significant auditory space map plasticity, particularly in juveniles.
  • Auditory spatial tuning in the ICX adapts to visual field shifts induced by prismatic spectacles.

Purpose of the Study:

  • To investigate experience-dependent axonal remodeling in the projection from the central nucleus of the inferior colliculus (ICC) to the ICX.
  • To determine if functional auditory plasticity is associated with structural changes in axonal projections.

Main Methods:

  • Utilized the anterograde tracer biocytin to visualize and analyze axonal projections from the ICC to the ICX.
  • Compared the density, sparseness, and spatial extent of axonal projection fields in normal juveniles, normal adults, and prism-reared adults.

Related Experiment Videos

Main Results:

  • Normal adult owls showed sparser and more restricted ICC-ICX projections compared to juveniles.
  • Prism-reared adult owls displayed denser and broader projection fields with increased bouton-laden axons in the ICX.
  • Prism experience induced topographically appropriate axonal sprouting and synaptogenesis, enhancing adaptive auditory spatial information transfer.

Conclusions:

  • Functional plasticity in the barn owl's auditory space map is accompanied by significant axonal remodeling.
  • Experience-driven axonal sprouting and synaptogenesis form adaptive neuronal circuits for altered sensory input.
  • The preservation of normal projection zones alongside new growth suggests the potential for dual spatial maps, facilitating readaptation.