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Tanning salon exposure and molecular alterations.
S E Whitmore1, W L Morison, C S Potten
1Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Journal of the American Academy of Dermatology
|April 20, 2001
Summary
Tanning salon UV exposure causes DNA damage and p53 protein expression in skin cells, similar to sun exposure. These molecular changes are linked to skin cancer development.
Area of Science:
- Dermatology
- Molecular Biology
- Photobiology
Background:
- Limited human studies exist on the short-term cellular effects of tanning salon use.
- Understanding these effects is crucial for consumer education regarding tanning salon risks.
Purpose of the Study:
- To investigate DNA alterations and p53 protein expression in skin cells and lymphocytes after tanning salon exposure.
- To assess the cellular impact of artificial UV radiation from tanning beds.
Main Methods:
- Eleven subjects underwent 10 tanning salon sessions over two weeks.
- DNA cyclobutane pyrimidine dimers and p53 protein levels were analyzed in skin biopsies and blood samples before and after exposure.
Main Results:
- DNA damage (cyclobutane pyrimidine dimers) and p53 protein were detected in epidermal keratinocytes.
- No significant alterations were observed in circulating peripheral lymphocytes.
Conclusions:
- Tanning salon exposure induces molecular changes in skin cells, mirroring effects of natural sunlight.
- These UV-induced alterations are considered critical early steps in skin carcinogenesis.