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Intracameral and lenticular penetration of locally applied stable isotope-labeled vitamin E
1Department of Ophthalmology, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Purpose:
To confirm the aqueous humor and lens dynamics of 1% deuterium-labeled alpha-tocopherol acetate (D(3)-VEA) solution.
Methods:
The concentrations of D(3)-VEA and D(3)-alpha-tocopherol (D(3)-VE), derived from D(3)-VEA, in the aqueous humor and lens were measured after continuous instillation of 1% D(3)-VEA into the cul-de-sac of rat eyes for 1 or 3 weeks. D(3)-VEA and D(3)-VE concentrations were determined by gas chromatography/mass selective detector.
Results:
In the aqueous humor, the concentrations of D(3)-VEA and D(3)-VE were, respectively, 93.1 and 9.4 ng/mL after 1 week, and, respectively, 498.9 and 21.5 ng/mL after 3 weeks. In the lens, they were, respectively, 15.0 and 9.8 ng/g after 1 week, and 6.1 and 4.8 ng/g after 3 weeks.
Conclusion:
The penetration levels of alpha-tocopherol acetate by eyedrop application were confirmed in the aqueous humor and lens.
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