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Factors associated with increased aqueous flare in psoriasis
F Okamoto1, Y Umebayasi, F Ohtsuka
1Department of Ophthalmology, University Hospital of Tsukuba, Tsukuba, Japan.
Japanese Journal of Ophthalmology
|April 21, 2001
Summary
Psoriasis patients exhibit elevated aqueous flare, indicating subclinical blood-aqueous barrier damage. Psoriasis severity, particularly the Psoriasis Area and Severity Index, is the primary factor influencing flare levels.
Area of Science:
- Ophthalmology
- Dermatology
- Immunology
Background:
- Psoriasis is a chronic inflammatory disease with potential systemic manifestations.
- Ocular involvement in psoriasis, though often asymptomatic, can affect the anterior chamber.
Purpose of the Study:
- To quantify aqueous flare in psoriasis patients.
- To identify clinical and biochemical factors associated with aqueous flare in psoriasis.
Main Methods:
- Laser flare-cell photometry was used to measure aqueous flare in 34 psoriasis patients and 34 healthy controls.
- Comprehensive dermatologic and ophthalmic examinations were conducted on psoriasis patients.
Main Results:
- Psoriasis patients showed significantly higher aqueous flare compared to controls (P <.0001).
- Increased flare correlated with older age and higher Psoriasis Area and Severity Index (PASI) scores.
- Flare levels were significantly associated with serum total protein and immunoglobulin A (IgA).
Conclusions:
- Psoriasis patients experience subclinical blood-aqueous barrier compromise, even without overt ocular symptoms.
- The severity of psoriasis, as measured by PASI, is the strongest predictor of aqueous flare.