Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Gene expression profiling in human mesothelioma cells using DNA microarray and high-density filter array

S Mohr1, B Rihn

  • 1Laboratoire de cancérogenèse in vivo, Institut national de recherche et de sécurité, avenue de Bourgogne, BP 27, 54501 VandOEuvre-lès-Nancy.

Bulletin Du Cancer
|April 21, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Needs and wishes of Gen Z medical students: a prospective cross sectional single center study.

Langenbeck's archives of surgery·2026
Same author

Simulated shared and supported decision making for amyloid immunotherapy in Alzheimer's disease: A bicentric study.

Revue neurologique·2026
Same author

[Short version of the S2k guideline on drug therapy of neurogenic lower urinary tract dysfunction (NLUTD)].

Urologie (Heidelberg, Germany)·2022
Same author

[Acute management of spontaneous intracerebral hemorrhage].

La Revue de medecine interne·2021
Same author

[Management of ischemic stroke in the acute phase].

La Revue de medecine interne·2021
Same author

Immune Signature of Malignant Pleural Mesothelioma as Assessed by Transcriptome Analysis.

Cancer genomics & proteomics·2019
Same journal

[ONCONNECTE À L'EMPLOI, feedback after three years of a program to prepare for returning to work after cancer in Franche-Comté].

Bulletin du cancer·2026
Same journal

[Off-label use of venetoclax in myeloma].

Bulletin du cancer·2026
Same journal

[Cemiplimab - Adjuvant treatment for the cutaneous squamous cell carcinomas with high risk of relapse, operated and treated by radiotherapy].

Bulletin du cancer·2026
Same journal

Real-world outcomes and management of endometrial cancer in France from 2016 to 2021 (MOONBEAM study).

Bulletin du cancer·2026
Same journal

[Cardiotoxicity in children and adolescents with acute leukemia: Recommendations from the Leukemia Committee of the French Society of Childhood Cancer (SFCE)].

Bulletin du cancer·2026
Same journal

[Reirradiation: A new therapeutic paradigm in oncology].

Bulletin du cancer·2026
See all related articles

Asbestos exposure causes cancer. Researchers compared gene expression in normal pleural cells and mesothelioma cells, identifying potential new biomarkers for diagnosing and treating this asbestos-related cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Public Health

Context:

  • Asbestos is a known human carcinogen, posing significant public health risks despite bans.
  • It is linked to serious pulmonary diseases, including malignant mesothelioma.
  • Understanding the molecular changes in pleural cells is crucial for combating asbestos-related cancers.

Purpose:

  • To compare gene expression profiles between normal mesothelium cells and malignant mesothelioma cells.
  • To identify novel molecular markers associated with mesothelioma development and progression.
  • To elucidate the genetic alterations underlying the transformation of pleural cells.

Summary:

  • Gene expression analysis was performed on normal mesothelium (Met-5A) and mesothelioma (MSTO-211H) cell lines using high-density filter arrays and microarrays.

Related Experiment Videos

  • Data analysis facilitated the hierarchical classification of genes by function and pathway, characterizing both normal and malignant phenotypes.
  • Quantitative RT-PCR validated the expression levels of key genes, confirming the findings.

    • Impact:

    • The study identified potential new biomarkers for mesothelioma.
    • These markers could aid in the diagnosis, prognosis, and therapeutic strategies for asbestos-induced mesothelioma.
    • This research contributes to a better understanding of mesothelioma's molecular underpinnings.