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Baculoviruses and apoptosis: the good, the bad, and the ugly

R J Clem1

  • 1Division of Biology, Kansas State University, Manhattan 66506, USA. rclem@ksu.edu

Cell Death and Differentiation
|April 21, 2001
PubMed

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Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size reduction of the tissue.
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The Extrinsic Apoptotic Pathway

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