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Peyronie's disease in men under age 40: characteristics and outcome
A Tefekli1, E Kandirali, H Erol
1Department of Urology, Medical Faculty of Istanbul, University of Istanbul, Turkey.atefekli@anet.net.tr
Insights
Younger men with Peyronie's disease (PD) often experience acute symptoms, including pain and curvature. Early intervention may be necessary due to the aggressive nature of PD in this demographic.
Area of Science:
- Urology
- Andrology
- Men's Health
Background:
- Peyronie's disease (PD) typically affects middle-aged men.
- However, younger individuals can also develop PD, presenting unique clinical characteristics.
- Understanding these differences is crucial for appropriate management.
Purpose of the Study:
- To investigate the prevalence and clinical features of Peyronie's disease in men under 40.
- To analyze the disease progression and outcomes in this younger cohort.
- To compare the presentation and course of PD in younger versus older patients.
Main Methods:
- Retrospective review of Peyronie's disease patients over a 6-year period.
- Focus on patients diagnosed under the age of 40.
- Analysis of presenting symptoms, penile curvature, erectile dysfunction, and follow-up outcomes.
Main Results:
- Patients under 40 represented 8.2% of the PD cohort, with a mean age of 32.47 years.
- 78.9% presented during the acute phase, often with penile pain (52.6%).
- Penile curvature < 60 degrees was common (84%), and 21% had erectile dysfunction.
Conclusions:
- Peyronie's disease onset in men under 40 is frequently acute and symptomatic.
- This demographic may require more aggressive or timely treatment strategies.
- Disease progression varied, with improvement, stability, or deterioration observed over follow-up.
Abstract:
Peyronie's disease is most commonly seen in the fifth decade of life. However, a wide range of age (20-83 y) is reported. During a 6-year period, men with Peyronie's disease presenting under the age of 40 were reviewed retrospectively and followed-up. The prevalence of Peyronie's patients presenting under age 40 was 8.2%. Their mean age was 32.47 +/- 5.37 (range: 23-39) y and 78.9% of them presented during the acute phase of the disease. Pain on erection was a part of presenting symptom complex in 52.6% and the majority (84%) had a degree of penile curvature < 60 degrees. Erectile dysfunction (ED) was present in 21% of patients, who responded well to intracavernous injection test. After a minimal 2-year follow-up, improvement in penile deformity was observed in 36.8%, and 42.1% had stable disease while 21% experienced deterioration of the penile curvature. The onset of Peyronie's disease is clinically more noisy and acute in patients presenting under age 40 and this forces the physicians to treat them more vigorously.