Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protease activated receptors: theme and variations.

P J O'Brien1, M Molino, M Kahn

  • 1Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Oncogene
|April 21, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Modified Ashworth and Modified Tardieu Scales differ in their classification of lower limb spasticity.

Clinical rehabilitation·2025
Same author

Status quo after one year of COVID-19 pandemic in otolaryngological hospital-based departments and private practices in Germany.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2021
Same author

An audit of the outcomes of the College of Surgeons general surgery final examinations.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2019
Same author

Platelet packing density is an independent regulator of the hemostatic response to injury.

Journal of thrombosis and haemostasis : JTH·2018
Same author

The small-molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis.

Journal of thrombosis and haemostasis : JTH·2017
Same author

Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis.

Oncogene·2017

Protease-activated receptors (PARs) are G protein coupled receptors activated by proteases. This review details PAR signaling initiation and termination, exploring intramolecular and intermolecular activation modes.

Area of Science:

  • Biochemistry
  • Cellular Biology
  • Pharmacology

Background:

  • G protein-coupled receptors (GPCRs) mediate cellular responses.
  • Protease-activated receptors (PARs) are a unique class of GPCRs.
  • PARs are activated by proteolytic cleavage of tethered ligands.

Purpose of the Study:

  • To review recent findings on PAR signaling.
  • To elucidate mechanisms of PAR activation and termination.
  • To identify novel proteases activating PAR family members.

Main Methods:

  • Literature review of recent research on PARs.
  • Analysis of signaling pathways involved in PAR activation.
  • Discussion of experimental evidence for activation mechanisms.

Related Experiment Videos

Main Results:

  • Three PARs are thrombin receptors; PAR2 is activated by other proteases like trypsin and Factor Xa.
  • Evidence supports both intramolecular and intermolecular modes of PAR activation.
  • Ongoing research aims to discover new biologically relevant proteases for PAR activation.

Conclusions:

  • PAR activation involves complex proteolytic events.
  • Understanding PAR signaling is crucial for therapeutic development.
  • Further research is needed to fully characterize PAR-GPCR interactions.