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Related Experiment Videos

BoneSource solidification: a comparison between water and sodium phosphate as the solvent.

C M Barone1, D F Jimenez, M T Boschert

  • 1Division of Plastic Surgery, University of Missouri, One Hospital Drive, M349, Columbia, MI 65212, USA. BaroneC@health.missouri.edu

The Journal of Craniofacial Surgery
|April 21, 2001
PubMed
Summary

Adding sodium phosphate to BoneSource (hydroxyapatite cement) significantly reduces its solidification time from 99 to 43 minutes. This modification also maintains an isothermic reaction, improving cement handling properties.

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Area of Science:

  • Biomaterials Science
  • Surgical Materials Engineering
  • Orthopedic Materials Research

Background:

  • BoneSource, a hydroxyapatite cement, is utilized in orthopedic and dental applications.
  • The setting time and thermal properties of bone cements influence their clinical usability.
  • Optimizing cement handling characteristics is crucial for successful surgical procedures.

Purpose of the Study:

  • To evaluate the impact of sodium phosphate on the solidification rate of BoneSource.
  • To compare the setting times of BoneSource mixed with sterile water versus sodium phosphate solution.
  • To assess the thermal behavior of BoneSource during solidification with different mixing agents.

Main Methods:

  • BoneSource (hydroxyapatite cement) was prepared using two distinct mixing agents: sterile water and a 0.25 ml sodium phosphate solution.

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  • The time required for complete solidification (cure time) was meticulously recorded for each mixture.
  • The temperature profile during the solidification process was monitored for both BoneSource formulations.

    • Main Results:

    • BoneSource mixed with sterile water exhibited an average cure time of 99 minutes (SD 5.3).
    • BoneSource mixed with sodium phosphate demonstrated a significantly reduced average cure time of 43 minutes (SD 3.6) (P < 0.0003).
    • The average solidification temperature for BoneSource in sterile water was 19.1°C (SD 0.082), compared to 20.1°C (SD 0.1) in sodium phosphate, indicating an isothermic reaction.

    Conclusions:

    • Sodium phosphate significantly accelerates the solidification rate of BoneSource hydroxyapatite cement.
    • The use of sodium phosphate results in a substantially shorter working time for BoneSource.
    • BoneSource mixed with sodium phosphate maintains an isothermic reaction, suggesting improved predictability and handling during application.