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Related Experiment Videos

CT-determined intracranial volume for a normal population.

A H Abbott1, D J Netherway, D B Niemann

  • 1Australian Cranio-Facial Unit, Women's and Children's Hospital, 72 King William Road, North Adelaide, SA 5006 Australia.

The Journal of Craniofacial Surgery
|April 21, 2001
PubMed
Summary

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This study establishes new reference curves for intracranial volume in a normal white population using computed tomography. Findings reveal differences compared to existing data, particularly in early childhood, impacting craniosynostosis assessments.

Area of Science:

  • Neuroimaging
  • Pediatric Radiology
  • Human Anatomy

Background:

  • Existing intracranial volume reference data may be inaccurate, potentially affecting diagnoses like craniosynostosis.
  • Computed tomography (CT) offers a precise method for measuring intracranial volume.

Purpose of the Study:

  • To establish normative intracranial volume reference curves for a white population using CT data.
  • To compare these new curves with existing historical references.
  • To refine understanding of intracranial volume development in children.

Main Methods:

  • Intracranial volumes of 157 white subjects (82 female, 75 male) were measured using CT and the Cavalieri estimator.
  • Monomolecular and Gompertz models were applied to fit intracranial volume as a function of age.

Related Experiment Videos

  • The monomolecular model provided the best fit using logarithmically transformed intracranial volume and age from conception.

    • Main Results:

    • New intracranial volume reference curves were generated for males and females.
    • Male and female curves showed similar growth patterns, but females had a lower mean volume at age 20.
    • The new male curves were higher than historical references (Blinkov, Lichtenberg, Dekaban) from 8 months to 4 years.
    • The new female curves differed from Lichtenberg's, particularly after 41 months.

    Conclusions:

    • The developed CT-based intracranial volume curves provide a more current reference for a white population.
    • Significant deviations from historical data suggest a need to update reference materials for conditions like craniosynostosis.
    • Ninety-five percent of final intracranial volume is reached by approximately 42 months for girls and 46 months for boys.