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Updated: Aug 2, 2026
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Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
Published on: January 12, 2017
Pulpal evaluation of two adhesive systems in rat teeth
The Journal of Clinical Pediatric Dentistry
|April 21, 2001
Summary
This study investigated dentinal adhesives for primary tooth pulpotomies, finding that Syntac and Prime & Bond NT caused inflammation and necrosis, with no dentinal bridge formation in rat teeth.
Area of Science:
- Dentistry
- Biomaterials
Background:
- Formocresol, a common pulpotomy agent, faces scrutiny due to potential toxicity.
- Dentinal adhesives are being explored as alternatives for treating pulpal exposures.
Purpose of the Study:
- To evaluate the pulpal response to Syntac and Prime & Bond NT dentinal adhesives in rat teeth with pulpal exposures.
Main Methods:
- Pulpal exposures were created in rat molars.
- Two dentinal adhesives, Syntac and Prime & Bond NT, were applied.
- Histological evaluation using light microscopy was performed after 45 days.
Main Results:
- Both Syntac and Prime & Bond NT groups exhibited chronic inflammation.
- Absence of dentinal bridge formation was observed in all treated specimens.
- Necrosis and irregular odontoblastic layers were noted in the pulps.
Conclusions:
- Dentinal adhesives Syntac and Prime & Bond NT did not promote healing or dentinal bridge formation in pulpal exposures.
- These adhesives were associated with persistent inflammation and pulpal damage in the rat model.
