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Updated: Aug 15, 2026
Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
Intratympanic dexamethasone for sudden sensorineural hearing loss: clinical and laboratory evaluation
1Division of Otolaryngology-HNS, UMDNJ-New Jersey Medical School and University Hospital, Newark, USA.
Objective:
To discuss the value of intratympanic dexamethasone (IT-DEX) perfusion for sudden sensorineural hearing loss (SSNHL), clinically and in an animal model.
Study Design:
Retrospective case review of 10 patients with SSNHL treated with IT-DEX. The findings are correlated with this institution's previous findings from a study of IT-DEX in guinea pigs.
Setting:
Ambulatory tertiary otologic referral center.
Patients:
Sequential patients with SSNHL who chose IT-DEX treatment.
Interventions:
Dexamethasone 0.5 mg was injected transtympanically and bathed the round window for 20 minutes. Animal study: 79 ears were randomized into five groups: control, IT-DEX versus intravenous (IV)-DEX, IT-DEX with histamine, IT-DEX with hyaluronic acid, and IT-DEX with dimethylsulfoxide.
Main Outcome Measures:
Clinical study: postprocedure audiometry. Animal study: perilymph steroid concentration.
Results:
IT-DEX results in significant hearing improvement and in significantly higher perilymph concentration of steroid than IV-DEX.
Conclusions:
IT-DEX is an appropriate treatment option for the treatment of SSNHL. Further study of dosages and frequency of administration is warranted.
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