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Kidney depth measurements using a double isotope technique.

S T Ostrowski, P Tothill

    The British Journal of Radiology
    |April 1, 1975
    PubMed
    Summary
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    Kidney depth variations can distort renograms. A double isotope method found distortions acceptable with 131-I Hippuran, but potentially excessive with 125-I Hippuran, despite reduced extrarenal activity.

    Area of Science:

    • Nuclear Medicine
    • Medical Imaging
    • Renal Physiology

    Background:

    • Renal depth variations can cause renogram distortions due to attenuation and geometrical factors.
    • Accurate renogram interpretation requires accounting for these depth differences.

    Purpose of the Study:

    • To develop and assess a method for quantifying kidney depth variations.
    • To evaluate the impact of these variations on renogram accuracy using different isotopes.

    Main Methods:

    • Employed a double isotope technique using 125-I and 131-I Hippuran.
    • Calculated kidney depth based on the ratio of count-rates from the two isotopes.
    • Corrected for extrarenal activity using a third detector and doubly labeled human serum albumin.

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    Main Results:

    • Average kidney depth was 7.3 cm.
    • In 11 out of 13 patients, the difference in kidney depth between the two kidneys was less than 1 cm.
    • Intrarenal tracer translocation frequently caused an apparent increase in activity depth during the renogram.

    Conclusions:

    • Renogram distortions with 131-I Hippuran are generally acceptable.
    • Renogram distortions with 125-I Hippuran may be excessive, even with reduced extrarenal activity.
    • The developed method effectively assesses kidney depth variations impacting renogram analysis.