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Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
Published on: January 24, 2013
Modeling daily and subdaily cycles in rat sleep data
P Qiu1, R Chappell, W Obermeyer
1School of Statistics, University of Minnesota, Minneapolis 55455, USA. qiu@stat.umn.edu
Abstract:
We developed a statistical model for rat sleep-wake behavior over the 24-hour day; this model could be used for animals exposed to shorter cycles of light and dark conditions. Rat behavior was classified either as "wake" or "sleep," as determined by analysis of electrophysiological data. The proposed model consists of three parts: the first two explain cyclic effects relating to the lighting conditions, whereas the last part reflects any acyclic effect. Hypothesis tests were conducted on the magnitude of the parts. The model also accounts for correlated errors.

