Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Normal approximation diagnostics for the Cox model.

C C Chang1, L A Weissfeld

  • 1Department of Medicine, University of Pittsburgh, Pennsylvania 15213, USA. changj@vms.cis.pitt.edu

Biometrics
|April 21, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

cDNA sequence analysis and expression of the a chain of beta-bungarotoxin from Bungarus multicinctus (Taiwan banded krait).

Biochemical and biophysical research communications·1996
Same author

A comparison of the propensity for gene amplification between near-tetraploid and near-diploid V79 clones resistant to 150 nM methotrexate.

Carcinogenesis·1996
Same author

Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.

The EMBO journal·1995
Same author

Regulation and immunolocalization of acyl-coenzyme A: cholesterol acyltransferase in mammalian cells as studied with specific antibodies.

The Journal of biological chemistry·1995
Same author

Hydration, not silicone, modulates the effects of keratinocytes on fibroblasts.

The Journal of surgical research·1995
Same author

cDNA sequence analysis and expression of alpha-bungarotoxin from Taiwan banded krait (Bungarus multicinctus).

Biochemical and biophysical research communications·1995
Same journal

Fast penalized generalized estimating equations for large longitudinal functional datasets.

Biometrics·2026
Same journal

Causally-interpretable random-effects meta-analysis.

Biometrics·2026
Same journal

Statistical inference for mean function of partially observed functional time series.

Biometrics·2026
Same journal

Subgroup identification via Interaction Tree and Mixed Model for Repeated Measures with application to Alzheimer's disease.

Biometrics·2026
Same journal

Finite mixtures of linear quantile regressions with concomitant variables: a solution to endogeneity in longitudinal data modeling.

Biometrics·2026
Same journal

Discussion on "INTACT: a method for integration of longitudinal physical activity data from multiple sources" by Jingru Zhang, Erjia Cui, Hongzhe Li, and Haochang Shou.

Biometrics·2026
See all related articles

New diagnostic methods assess the accuracy of confidence regions in the Cox proportional hazards model for censored data. These methods extend existing contour and curvature measures, offering improved reliability for survival analysis.

Area of Science:

  • Statistics
  • Biostatistics
  • Survival Analysis

Background:

  • The Cox proportional hazards model is widely used for analyzing time-to-event data, especially with censored observations.
  • Assessing the accuracy of confidence regions is crucial for reliable statistical inference.
  • Existing diagnostic methods have limitations in evaluating the normal approximation to likelihood-based confidence regions.

Purpose of the Study:

  • To introduce and evaluate two novel diagnostic methods for assessing the accuracy of normal approximated confidence regions.
  • To extend established contour and curvature measures for enhanced diagnostic capabilities.
  • To validate the proposed methods using real-world clinical data.

Main Methods:

  • Development of diagnostic methods based on extensions of contour measures (Hodges, Cook & Tsai) and curvature measures (Jennings, Cook & Tsai).

Related Experiment Videos

  • Application of these methods to assess the normal approximation of confidence regions in the Cox proportional hazards model.
  • Illustration with two case studies: hepatocyte growth factor in lung cancer and a Mayo Clinic primary biliary cirrhosis trial.

    • Main Results:

    • The proposed diagnostic methods provide a more accurate assessment of the normal approximated confidence region compared to existing techniques.
    • The methods effectively identify potential discrepancies between the approximated and likelihood-based confidence regions.
    • Case study applications demonstrate the practical utility and reliability of the new diagnostic tools.

    Conclusions:

    • The introduced diagnostic methods enhance the reliability of confidence region assessment in Cox proportional hazards models with censored data.
    • These extensions offer valuable tools for biostatisticians and researchers conducting survival analyses.
    • Improved accuracy in confidence region evaluation leads to more robust conclusions in clinical and epidemiological studies.