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The variance for the disequilibrium coefficient in the individual Hardy-Weinberg test
1Department of Integrative Biology, University of California at Berkeley, 94720-3140, USA. chenjj@slu.edu
Biometrics
|April 21, 2001
Abstract:
It is of interest to detect the deviation from Hardy-Weinberg proportion (HWP) for a particular heterozygote. Hernández and Weir (1989, Biometrics 45, 53-70) suggested a disequilibrium coefficient approach and proposed a 1-d.f. chi2 test. This note derives the appropriate variance under the null hypothesis for performing this individual HWP test. Examples of applying the test to human genetic disease data are presented.