Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tumours may be innervated.

P Seifert1, M Spitznas

  • 1Alfried-Krupp Laboratory, Department of Ophthalmology, University of Bonn, Germany. umc001@uni-bonn.de

Virchows Archiv : an International Journal of Pathology
|April 24, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Awake fibreoptic intubation in pronounced thyroid enhancement : Aspects of airway management].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2020
Same author

Severe persistent nasolacrimal duct obstruction: a typical finding in ADULT syndrome.

The British journal of ophthalmology·2006
Same author

Histopathologic evaluation of aneurysms treated with Guglielmi detachable coils or matrix detachable microcoils.

AJNR. American journal of neuroradiology·2006
Same author

[Ernst Abbe, the founder of modern optics].

Klinische Monatsblatter fur Augenheilkunde·2004
Same author

An implanted hamster greene melanoma expressing multiple host-tissue differentiation.

Journal of submicroscopic cytology and pathology·2003
Same author

Short-term reaction of choroidal neovascularization and choriocapillaris to photodynamic therapy in age-related macular degeneration.

European journal of ophthalmology·2003
Same journal

Role of INSM1 expression in the diagnostic work-up of pancreatic acinar cell carcinoma with special reference to the differential diagnosis with neuroendocrine tumor.

Virchows Archiv : an international journal of pathology·2026
Same journal

Mismatch repair protein deficiency (MMRd) and high microsatellite instability (MSI-H) in gastrointestinal stromal tumour (GIST) - a case report and review of the literature of this exceedingly rare phenotype.

Virchows Archiv : an international journal of pathology·2026
Same journal

Primary renal synovial sarcoma: a clinicopathological study of 23 cases highlighting the diagnostic value of SS18-SSX, TLE1, and INI1 immunohistochemistry panel.

Virchows Archiv : an international journal of pathology·2026
Same journal

Clinicopathologic characteristics of uterine malignant epithelioid neoplasms with EWSR1::CREM fusion: Report of 2 cases at a novel site with literature review.

Virchows Archiv : an international journal of pathology·2026
Same journal

Gallbladder MiNEN arising in association with an intracholecystic papillary neoplasm exhibiting divergent p53 expression.

Virchows Archiv : an international journal of pathology·2026
Same journal

Penile squamous cell carcinomas with the usual-type morphology can be HPV-associated - Routine p16/HPV testing should be performed in all penile squamous cell carcinomas regardless of morphology.

Virchows Archiv : an international journal of pathology·2026
See all related articles

Tumours are often assumed to lack nerves. However, this study found nerve fibres within two human eye adenomas, suggesting some tumours may be innervated.

Area of Science:

  • Ophthalmology
  • Oncology
  • Neuroscience

Background:

  • Tumours are generally considered non-innervated.
  • Previous assumptions questioned by an accidental observation of nerve fibers in an eye adenoma.

Purpose of the Study:

  • To investigate the presence of nerve tissue in adenomas of the ciliary body epithelium.
  • To ultrastructurally evaluate pigmented and non-pigmented adenomas for nerve fibers.

Main Methods:

  • Surgical removal of two human eye adenomas (pigmented and non-pigmented).
  • Ultrastructural evaluation using transmission electron microscopy.
  • Systematic screening for nerve tissue within the tumour samples.

Main Results:

  • Both adenomas (pigmented and non-pigmented) contained fine unmyelinated nerve fibers.

Related Experiment Videos

  • Nerve fibers were observed in the tumor periphery near blood vessels and tumor cells.
  • In one adenoma, nerve fibers were also found in more central areas.

    • Conclusions:

    • This study provides evidence of nerve fiber presence in ciliary body epithelium adenomas.
    • The findings challenge the assumption that tumours are not innervated.
    • Further research is needed to confirm and understand the implications of innervated tumours.