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Postmenopausal osteoporosis: microradiographic aspects.

A Dhem1, C Nyssen-Behets, J Coppens

  • 1Human Anatomy Research Unit, Université Catholique de Louvain, Brussels. dhem@belbone.be

Italian Journal of Anatomy and Embryology = Archivio Italiano Di Anatomia Ed Embriologia
|April 24, 2001
PubMed
Summary
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Bone surfaces undergo a unique erosion process called delitescence, unrelated to osteoclasts, contributing to age-related bone loss. This finding applies to both men and women, irrespective of osteoporosis severity.

Area of Science:

  • Bone biology
  • Skeletal aging
  • Histopathology

Background:

  • Bone remodeling is crucial for skeletal integrity.
  • Age-related bone loss and osteoporosis are significant health concerns.
  • The mechanisms behind bone loss, particularly in postmenopausal women, require further elucidation.

Purpose of the Study:

  • To investigate the morphological changes in bone surfaces in relation to aging.
  • To identify potential cellular or non-cellular processes contributing to bone loss.
  • To compare these changes between sexes and different age groups.

Main Methods:

  • Comparative microradiographic and histologic analysis of undecalcified bone samples.
  • Examination of bone from individuals aged 18-98 years.

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  • Morphological assessment of haversian canals, vascular canals, and trabecular surfaces.

    • Main Results:

    • A novel bone surface alteration, termed 'delitescence,' was observed.
    • Delitescence involves weathering of superficial lamellae on quiescent bone surfaces, without osteoclast involvement.
    • These erosive changes were present from early adulthood, randomly distributed, and similar in both sexes, irrespective of osteoporosis grade.
    • Estrogen deficiency's role in increasing dead osteocytes and impairing bone repair was hypothesized.

    Conclusions:

    • Delitescence is a previously unrecognized destructive process affecting quiescent bone surfaces.
    • This process may significantly contribute to age-related bone loss and postmenopausal osteoporosis.
    • Understanding delitescence could offer new therapeutic targets for skeletal aging and osteoporosis.