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Genetic interference in protozoa
P Bastin1, A Galvani, L Sperling
1University of Manchester, School of Biological Sciences, UK.
Research in Microbiology
|April 24, 2001
Abstract:
RNA interference first described in Caenorhabditis elegans and transgene-induced post-transcriptional gene silencing first described in plants and fungi now appear as different means of activating a conserved and ancient mechanism that can protect genomes against viruses and transposons and perhaps also control expression of endogenous genes. We present here similar genetic interference phenomena in highly divergent protozoa, Trypanosoma and Paramecium, and look ahead to what contribution these microorganisms could bring to this fast-moving area.