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Factors affecting pulsatile ocular blood flow in normal subjects
1Department of Ophthalmology, Asahikawa Medical College, Midorigaoka Higashi 2-1-1-1, Asahikawa 078-8510, Japan. morinao@d5.dion.ne.jp
The British Journal of Ophthalmology
|April 24, 2001
Summary
Pulsatile ocular blood flow (POBF) decreases as axial length increases in normal subjects. Axial length is a significant factor influencing POBF, potentially impacting choroidal blood flow.
Area of Science:
- Ophthalmology
- Ocular Physiology
- Biomedical Engineering
Background:
- Pulsatile ocular blood flow (POBF) is crucial for maintaining eye health.
- Understanding factors influencing POBF is essential for diagnosing and managing ocular conditions.
Purpose of the Study:
- To investigate the relationship between various physiological factors and POBF in healthy individuals.
- To identify key determinants of POBF in a normal population.
Main Methods:
- POBF was measured in 80 healthy subjects using Langham OBF computerised tonometry.
- Multiple regression analysis was employed to assess the influence of age, blood pressure, refractive error, intraocular pressure, and axial length on POBF.
Main Results:
- The average POBF was 593.3 (203.6) microl/min.
- Axial length was the only statistically significant factor (p = 0.008) influencing POBF.
- A negative regression coefficient indicated that increased axial length was associated with decreased POBF.
Conclusions:
- POBF tends to decrease with increasing axial length in normal subjects.
- Increased axial length may lead to reduced choroidal blood flow.
- Axial length appears to be a primary determinant of POBF.