Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rational use of toxicology testing in children.

R J Hoffman1, L Nelson

  • 1New York City Poison Control Center, New York, New York, USA. rjhoffman@pol.net

Current Opinion in Pediatrics
|April 24, 2001
PubMed
Summary

Laboratory toxicology testing aids in managing poison exposures, but comprehensive screening in children is often costly and ineffective. Focused quantitative assays and careful application of drug of abuse testing are more beneficial.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Innovative clearance data model for demining operational data collection: Insights from field trials in Zimbabwe.

Heliyon·2024
Same author

Operational data for the risk management of victim operated explosive devices in humanitarian mine action: A Practitioner's perspective.

Heliyon·2024
Same author

Roadmap to DILI research in Europe. A proposal from COST action ProEuroDILINet.

Pharmacological research·2023
Same author

The 10-year trajectory of aggressive behaviours in autistic individuals.

Journal of intellectual disability research : JIDR·2023
Same author

Low speech rate but high gesture rate during conversational interaction in people with Cornelia de Lange syndrome.

Journal of intellectual disability research : JIDR·2021
Same author

Author Correction: Proteomic and Transcriptomic Changes in Hibernating Grizzly Bears Reveal Metabolic and Signaling Pathways that Protect against Muscle Atrophy.

Scientific reports·2020

Area of Science:

  • Clinical Toxicology
  • Laboratory Medicine
  • Pediatric Emergency Medicine

Background:

  • Poison exposures are common, particularly in children, necessitating effective diagnostic tools.
  • Laboratory assays, from basic to specialized, play a role in evaluating poisoned patients.
  • Existing literature on poisoning in pregnant patients and specific pediatric toxicology is reviewed.

Purpose of the Study:

  • To evaluate the utility and limitations of various laboratory toxicology assays in patient management.
  • To assess the cost-effectiveness and clinical impact of comprehensive toxicology screening in pediatrics.
  • To review the application of drug of abuse testing, including hair sampling, and associated pitfalls.

Main Methods:

  • Review of literature on poisoning in pregnant patients and recommendations for pregnancy testing.

Related Experiment Videos

  • Analysis of recent studies on pediatric toxicology screening costs and management impact.
  • Evaluation of focused quantitative serum assays and drug of abuse testing methods.

    • Main Results:

    • Comprehensive toxicology screening in pediatric patients is often expensive and does not alter management for most cases.
    • Focused quantitative serum assays are useful for determining specific poison levels.
    • The capabilities and limitations of drug of abuse testing, including hair sampling, are analyzed.

    Conclusions:

    • Indiscriminate or misinterpreted toxicology testing can lead to significant pitfalls.
    • Selective use of quantitative assays and appropriate drug of abuse testing is recommended.
    • Cost-effective laboratory strategies are crucial for managing poison exposures, especially in pediatric populations.