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Mechanisms underlying human motor system plasticity.

B Boroojerdi1, U Ziemann, R Chen

  • 1Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5N 234, 10 Center Drive, MSC 1428, Bethesda, Maryland 20892-1428, USA.

Muscle & Nerve
|April 24, 2001
PubMed
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The adult nervous system exhibits plasticity, allowing reorganization and adaptation. This review explores how the human motor system changes and how these changes can be modulated.

Area of Science:

  • Neuroscience
  • Neuroplasticity research
  • Human motor system studies

Background:

  • The adult human nervous system's capacity for lifelong reorganization and adaptation is termed plasticity.
  • Plastic changes in the cerebral cortex are studied at the level of cortical maps (body representation) and neuronal/synaptic levels (synaptic efficacy, synapse generation).

Purpose of the Study:

  • To review paradigms for studying plasticity mechanisms in the intact human motor system.
  • To discuss the functional relevance of neuroplasticity.
  • To explore methods for modulating plasticity.

Main Methods:

  • Review of existing research paradigms.
  • Analysis of studies on the intact human motor system.
  • Examination of synaptic and cortical map modifications.

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Main Results:

  • Identified key paradigms for studying motor system plasticity.
  • Highlighted the functional significance of adaptive neural changes.
  • Discussed potential strategies for modulating neuroplasticity.

Conclusions:

  • Neuroplasticity is a fundamental property of the adult human nervous system.
  • Understanding plasticity mechanisms is crucial for therapeutic interventions.
  • Modulating plasticity offers potential for rehabilitation and functional recovery.