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Related Experiment Videos

FHIT gene expression in human urinary bladder transitional cell carcinomas.

A S Skopelitou1, G Gloustianou, M Bai

  • 1Department of Pathology, Ioannina University School of Medicine, Ioannina, Greece. antiskop@usa.net

In Vivo (Athens, Greece)
|April 25, 2001
PubMed
Summary
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Reduced expression or absence of the Fragile Histidine Triad (FHIT) gene product correlates with advanced bladder cancer stages. FHIT gene inactivation appears to be a late event in urinary bladder carcinogenesis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Uropathology

Background:

  • The Fragile Histidine Triad (FHIT) gene is a known tumor suppressor.
  • Alterations in FHIT expression are implicated in various cancers.
  • Understanding FHIT's role in bladder cancer progression is crucial.

Purpose of the Study:

  • To investigate FHIT gene product expression in urinary bladder tumors.
  • To correlate FHIT expression with tumor characteristics and patient outcomes.

Main Methods:

  • Immunohistochemistry was performed on 110 formalin-fixed, paraffin-embedded urinary bladder tumor tissues.
  • The anti-Fhit antibody and Streptavidin-biotin peroxidase method were utilized.

Main Results:

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  • FHIT protein was absent in 27.27% and abnormally expressed in 29.08% of cases.
  • Diffuse FHIT expression was observed in 43.63% of tumors.
  • A significant correlation was found between FHIT absence/reduction and advanced clinical stage (p < 0.001).

    • Conclusions:

    • FHIT gene inactivation is a late event in bladder cancer development.
    • Reduced or absent FHIT protein expression is associated with advanced disease stage.
    • FHIT expression did not correlate with tumor recurrence or patient survival.