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[Low-dose cytosine-arabinoside (Ara-C) therapy for chronic myeloid leukemia]
K M Abdulkadyrov1, O A Rukavitsyn, V I Udal'eva
1Russian Research Institute of Hematology and Transfusiology, St. Petersburg.
Voprosy Onkologii
|April 25, 2001
Abstract:
The effects of low doses of cytosine-arabinoside (Ara-C) were studied in 17 patients with chronic myeloid leukemia: chronic, resistant to IFN and hydroxyurea therapy (including 4 cases of advanced chronic disease)--7, and tumor progression--10. Hematologic effect was recorded in 7 chronic patients tolerant to hydroxyurea and alpha-interferon therapy. Among 10 cases of tumor progression, chronic stage II was observed in 3, stabilization (tumor progression short of blastic crisis)--5, and without effect--1. Low-dose Ara-C treatment was considered effective in 15 (88%) out of 17 patients.