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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
Clinical and histopathological findings in two Turkish children with follicular bronchiolitis
1Klinische Abteilung für Pädiatrische Pulmonologie und Allergologie, Universitätsklinik für Kinder- und Jugendheilkunde, Auenbruggerplatz 30, 8036 Graz, Austria. martin.benesch@klinikum-graz.at
Insights
Follicular bronchiolitis, a cause of progressive airway obstruction in children, requires open lung biopsy for diagnosis. Treatment varies, with one child needing immunosuppression and the other stabilizing with less intensive care.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
- Pediatric Pathology
Background:
- Follicular bronchiolitis is a rare inflammatory lung disease.
- It can cause progressive airway obstruction in children.
- Diagnosis often requires invasive procedures.
Observation:
- Two Turkish children presented with progressive airway obstruction.
- Open lung biopsy confirmed follicular bronchiolitis in both cases.
- Clinical presentation included recurrent respiratory infections and dyspnea.
Findings:
- Patient 1 required immunosuppressive therapy for respiratory improvement.
- Patient 2 stabilized with systemic steroids and topical treatments.
- Treatment response varied significantly between the two cases.
Implications:
- Consider follicular bronchiolitis in pediatric cases of chronic bronchial obstruction.
- Open lung biopsy is crucial for definitive diagnosis.
- Tailored treatment strategies are essential for managing pediatric follicular bronchiolitis.
Unlabelled:
We report on two Turkish children who presented with progressive airway obstruction. Open lung biopsy revealed follicular bronchiolitis. The children were treated with systemic steroids and various topical medications. Whereas the respiratory situation of patient 1 required immunosuppressive therapy, the condition of patient 2 stabilised without systemic medication.
Conclusion:
Diagnosis of follicular bronchiolitis should be considered when children present with recurrent respiratory tract infections, progressive dyspnoea, and chronic bronchial obstruction. Children in whom follicular bronchiolitis is suspected should undergo open lung biopsy for confirmation of diagnosis.
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