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A locus affecting obesity in human chromosome region 10p12
R A Price1, W D Li, A Bernstein
1Center for Neurobiology and Behavior, University of Pennsylvania, 415 Curie Blvd., CRB-135b, Philadelphia, PA 19104, USA.
Aims/Hypothesis:
Obesity is a complex trait influenced by multiple genes. We evaluated linkage in three regions of human chromosome 10 previously linked to obesity-related phenotypes.
Methods:
We conducted non-parametric linkage analysis of obesity-related phenotypes in cohorts of 170 European-American and 43 African-American families having extremely obese and normal weight subjects.
Results:
We found support for linkage of an obesity phenotype (BMI > or = 27 kg/m2) in both cohorts, as well as in a combined analysis (European-American cohort, Z = 1.90, p = 0.03; African-American cohort, Z = 2.25, p = 0.014; combined cohort, Z = 2.55, p = 0.005).
Conclusion/Interpretation:
These results confirm previous reports of linkage in French and German families. The consistency of results across these four cohorts supports the localization of a quantitative trait locus influencing obesity to human chromosome region 10p12.