Adenocarcinoma of the endometrium in a teenager

Endometrial carcinoma developed in a teenager with obesity, hypertension, hyperestrinism and lack of diurnal variation of plasma cortisol concentration. She underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy and is receiving estrogen therapy. Her six obese sisters and her mother, who are at risk for endometrial carcinoma, are being managed conservatively.