Related Experiment Video
Updated: Jun 21, 2026
04:22
Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
Published on: March 30, 2017
An easy-to-use dry-powder inhaler
1Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA.
Advances in Therapy
|April 25, 2001
Summary
This new mometasone furoate dry-powder inhaler simplifies asthma treatment with a three-step process. It ensures accurate medication delivery, supporting patient adherence for persistent asthma in adults and children.
Area of Science:
- Respiratory Medicine
- Pharmacology
- Medical Device Technology
Background:
- Persistent asthma requires consistent medication adherence for effective management.
- Topical corticosteroids are a cornerstone treatment for persistent asthma.
- Novel inhaler devices aim to improve drug delivery and patient compliance.
Purpose of the Study:
- To evaluate a novel mometasone furoate dry-powder inhaler (MF-DPI) designed for enhanced patient compliance.
- To assess the accuracy, uniformity, and precision of drug delivery from the MF-DPI across varying inspiratory flow rates.
- To determine the clinical efficacy of the MF-DPI in treating persistent asthma in adult and pediatric populations.
Main Methods:
- Development of a breath-actuated dry-powder inhaler utilizing a stabilized agglomerate formulation.
- Laboratory testing to evaluate dose measurement and delivery accuracy, uniformity, and precision.
- Clinical trials to assess the efficacy and usability of the MF-DPI in patients with persistent asthma.
Main Results:
- The MF-DPI demonstrated accurate, uniform, and precise drug delivery over a range of inspiratory flow rates.
- Laboratory and clinical data confirmed the device's effectiveness.
- The inhaler's simple three-step operation was designed to support patient compliance.
Conclusions:
- The novel mometasone furoate dry-powder inhaler is a clinically effective device for treating mild, moderate, and severe persistent asthma.
- The inhaler's design facilitates accurate corticosteroid delivery and supports improved patient adherence.
- This device offers a promising therapeutic option for adult and pediatric asthma patients aged 12 and older.
Related Concept Videos
01:25Antiasthma Drugs: β2-Adrenoceptor Agonists
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
01:26COPD: Management Using Bronchodilators and Corticosteroids
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
01:30Asthma-IV: Diagnostic and Management
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
01:23Inhaled Medications
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
01:22Drug Delivery: Miscellaneous Routes
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...