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Identification of phosphorodiamidic acid mustard as a human metabolite of cyclop hosphamide
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Abstract:
An active metabolite of cyclophosphamide, N,N-bis(2-chloroethyl)phosphorodiamidic acid, has been confirmed as a circulating and excreted metabolite in patients receiving the drug in therapy, by selected ion monitoring on a gas chromatograph mass spectrometer.
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