Two-stage design of quantal response studies
Related Experiment Video
Updated: Oct 8, 2026

Behavioral Assessment of Hearing in 2 to 4 Year-old Children: A Two-interval, Observer-based Procedure Using Conditioned Play-based Responses
Published on: January 23, 2017
1Department of Mathematics and Statistics, Simon Fraser University, Burnaby, British Columbia, Canada. sitter@cs.sfu.ca
Abstract:
In a quantal response study, there may be insufficient knowledge of the response relationship for the stimulus (or dose) levels to be chosen properly. Information from such a study can be scanty or even unreliable. A two-stage design is proposed for such studies, which can determine whether and how a follow-up (i.e., second-stage) study should be conducted to select additional stimulus levels to compensate for the scarcity of information in the initial study. These levels are determined by using optimal design theory and are based on the fitted model from the data in the initial study. Its advantages are demonstrated using a fishery study.
Related Concept Videos
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs
Group Design
Experimental Designs
Crossover Experiments
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
Factorial Design
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs
