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Published on: August 2, 2017
Amplitude modulation following responses in awake and sleeping humans--a comparison for 40 Hz and 80 Hz modulation
J Pethe1, H Von Specht, R Mühler
1Department of Experimental Audiology, Otto-von-Guericke-University, Magdeburg, Germany. joachim.pethe@medizin.uni-magdeburg.de
Abstract:
There have been several studies, which suggest that the amplitude of amplitude modulation following responses (AMFR) is correlated to the state of vigilance, similar to the 40 Hz event-related potentials. The aim of the present study was to compare the dependency of the AMFR-amplitude from the state of sleep for 40 Hz and 80 Hz modulation frequency. Eight normal hearing adults were investigated during natural and drug-induced sleep. The stimuli used were sinusoidally amplitude-modulated tones of 1 kHz carried frequency and 40 or 80 Hz modulation frequency at 60 dB nH stimulation level. For 40 Hz modulation frequency an increase of EEG-activity in the Delta-and Theta-band during periods of sleep correlates significantly with a decreased AMFR-amplitude whereas for 80 Hz no significant relation between stage of sleep and AMFR-amplitude could be found. The results suggest that in audiological use of 40 Hz-AMFR the state of vigilance should be monitored and stabilized at a high level.
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