The moth and the aspen tree: sodium in early postnatal development

Over the past 25 years, our perception of the neonatal kidney has changed markedly from its being a "limited" organ compared with that of the adult to being extraordinarily well adapted in its role in maintaining homeostasis and making possible the rapid somatic growth necessary during this critical period of life. The present review focuses on the physiologic adaptations by the neonatal kidney in the maintenance of a positive sodium balance, which is necessary for normal growth not only in mammals but also in moths. There is a fine interplay between the developing brain, heart, thyroid, adrenals, and sympathetic nervous system, all converging on the kidney to conserve sodium, which is limited in the diet. The renin-angiotensin system plays a central role in this response and is balanced by developmental changes in the renal response to atrial natriuretic peptide, all of which contribute to sodium conservation. Over the next 25 years, advances in molecular genetics will doubtless elucidate many more facets of the mechanisms underlying neonatal sodium homeostasis. This will be particularly important as the survival of ever smaller preterm infants improves steadily.