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[Current techniques for the clinical evaluation of the microcirculation].
1Unité de Médecine Vasculaire, Département Pluridisciplinaire de Médecine, CHU de Grenoble, 38043 Grenoble.
Journal Des Maladies Vasculaires
|April 25, 2001
Summary
Exploring human microcirculation involves clinimetric measurements, laser Doppler, and capillaroscopy. These methods quantify skin blood flow, tissue perfusion, and capillary structure, aiding therapeutic trials and research.
Area of Science:
- Physiology
- Biomedical Engineering
Context:
- Microcirculation assessment is crucial for understanding tissue health and disease.
- Current methods offer insights into hemodynamics, tissue perfusion, and structural integrity.
Purpose:
- To review current techniques for exploring human microcirculation.
- To highlight the utility of clinimetric measurements, laser Doppler, and capillaroscopy in clinical research and practice.
Summary:
- Clinimetric measurements (thermometry, chromametry, volumetry) quantify skin blood flow, volume, and edema.
- Laser Doppler provides semi-quantitative perfusion indices, useful for dynamic reactivity studies.
- Capillaroscopy, enhanced by videomicroscopes, visualizes capillary beds for microangiopathy assessment.
Impact:
- These methods aid in therapeutic trial evaluations and clinical routine diagnostics.
- Advanced techniques allow for depth-specific perfusion analysis and spatial heterogeneity mapping.
- Combining methods like laser Doppler and capillaroscopy enables detailed microvascular function assessment.