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[Embryo-fetal diseases in multiple pregnancies].
1Dipartimento di Discipline Ginecologichee Ostetriche, Cattedra B, Università degli Studi, Turin, Italy.
Minerva Ginecologica
|April 25, 2001
Summary
Multiple pregnancies significantly increase risks for severe fetal and neonatal damage, including premature birth and low birth weight. Early diagnosis and prevention are crucial for better outcomes in these high-risk pregnancies.
Area of Science:
- Obstetrics and Gynecology
- Perinatology
- Reproductive Medicine
Background:
- Multiple pregnancies present complex etiopathogenesis, including altered embryonic development.
- Prenatal and intranatal factors contribute to embryo-fetal diseases in multiple gestations.
- This biological situation carries a high potential for severe fetal and neonatal complications.
Purpose of the Study:
- To evaluate pathologies affecting fetuses in multiple pregnancies.
- To assess the risks of severe fetal and neonatal damage in multiple gestations.
- To understand the impact of multiple pregnancies on fetal development and outcomes.
Main Methods:
- Study included 205 patients with multiple pregnancies (199 bigeminal, 5 trigeminal, 1 quadrigeminal).
- Data collected from Turin University between 1989-1999.
- Embryo-fetal damage was assessed chronologically from zygotic to neonatal phase.
Main Results:
- Most pregnancies were biamniotic bichorionic (54%) or biamniotic monochorionic (45%).
- High rates of premature births (79.38%), small for gestational age (SGA) neonates, low birth weight (LBW, 66.84%), and very low birth weight (VLBW, 7.14%).
- Perinatal mortality (3.82%) was three times higher than in singleton pregnancies.
Conclusions:
- Severe embryo-fetal and neonatal damage is a significant reality in multiple pregnancies.
- Adequate diagnostic and therapeutic measures are essential.
- Specific medical and social prevention strategies are needed to mitigate maternal risks.