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Related Experiment Videos

Does obesity affect febrile responsiveness?

A I Ivanov1, V A Kulchitsky, A A Romanovsky

  • 1Trauma Research, St Joseph's Hospital and Medical Center, Phoenix, Arizona, USA. aivanov@chw.edu

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
|April 25, 2001
PubMed
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Obesity does not impair fever response in rats. Studies show obese rats with defective leptin or cholecystokinin-A receptors did not have decreased febrile responsiveness to bacterial endotoxins.

Area of Science:

  • Endocrinology
  • Immunology
  • Metabolic Research

Background:

  • Obesity is linked to reduced immunity and impaired infection resistance in humans and rodents.
  • Brown fat thermogenesis is suppressed in obese rodents, suggesting a potential link to altered fever responses.

Purpose of the Study:

  • To investigate whether obesity leads to decreased febrile responsiveness.
  • To test the hypothesis that obesity impairs the body's ability to generate fever.

Main Methods:

  • Compared fever responses to E. coli lipopolysaccharide in obese (Zucker fa/fa, OLETF) and lean (Fa/?, LOTO) rats.
  • Verified obesity through increased body mass, fat content, hypertriglyceridemia, and hypercholesterolemia.

Main Results:

Related Experiment Videos

  • Obese rats (Zucker fa/fa and OLETF) did not show decreased febrile responsiveness.
  • Fever responses in obese rats tended to be higher than in their lean counterparts.

    • Conclusions:

    • Obesity itself does not cause antipyresis (reduced fever).
    • The study refutes the hypothesis that obesity impairs fever generation.