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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
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Published on: February 12, 2017

Preoperative chemotherapy for non-small cell lung cancer

A Depierre1, V Westeel, P Jacoulet

  • 1Service de Pneumologie, Centre Hospitalier Universitaire Jean Minjoz, Boulevard Fleming, Besancon Cedex, 25030, France. pneumo-depierre@ufc-chu.univ-fcomte.fr

Cancer Treatment Reviews
|April 26, 2001
PubMed

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...