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Cerebral involvement in graft-versus-host disease after murine bone marrow transplantation
C S Padovan1, A Gerbitz, P Sostak
1Department of Neurology, Ludwig Maximilians University, Munich, Germany. padovan@brain.nefo.med.uni-muenchen.de
Neurology
|April 26, 2001
Abstract:
Neurologic manifestation of graft-versus-host disease (GvHD) after allogeneic bone marrow transplantation (BMT) has until now been limited to rare neuromuscular syndromes. Investigating cerebral findings using a murine BMT model, the authors found parenchymal lymphocytic inflammation, microglia activation, and mild cerebral angiitis-like changes in allogeneic transplanted animals but not in syngeneic controls. These findings suggest that cerebral involvement during GvHD may be a new neurologic complication after BMT.