Related Experiment Videos
[Developments in anti-malaria agents: chemical data, structure-activity relationships]
1Pharmacie chimique - Chimie thérapeutique UFR de Pharmacie 3, rue du Professeur-Laguesse F 59045 Lille Cedex, France.
Annales Pharmaceutiques Francaises
|April 26, 2001
Abstract:
Various features of the evolution of a few antimalarial drugs including amodiaquine, dihydrofolate-reductase inhibitors, and artemisinin are described. The mechanism of action of artemisinin is detailed to explain the information of the main metabolites and drug design of certain compounds. Structure-activity and structure-neurotoxicity relations are reported. A few examples of cyclic peroxycetal synthesis are given. Finally, trends in new and novel compounds are presented.