Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cerebral edema.

O Kempski1

  • 1Institute for Neurosurgical Pathophysiology, Johannes Gutenberg-University Mainz, Germany. Oliver.Kempski@uni-mainz.de

Seminars in Nephrology
|April 26, 2001
PubMed
Summary
This summary is machine-generated.

Brain edema involves intracellular (cytotoxic) or extracellular (vasogenic) fluid accumulation. Cytotoxic edema stems from energy failure affecting ion transport, while vasogenic edema results from blood-brain barrier damage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative analysis of in situ versus ex situ perfusion on micro circulation in liver procurement--an experimental trial in a porcine model.

Transplantation proceedings·2013
Same author

Neuroprotective effect of ceftriaxone on the penumbra in a rat venous ischemia model.

Neuroscience·2013
Same author

Erythropoietin neuroprotection is enhanced by direct cortical application following subdural blood evacuation in a rat model of acute subdural hematoma.

Neuroscience·2013
Same author

Continuous intraoperative monitoring of autonomic nerves during low anterior rectal resection: an innovative approach for observation of functional nerve integrity in pelvic surgery.

Langenbeck's archives of surgery·2012
Same author

Effects of a small acute subdural hematoma following traumatic brain injury on neuromonitoring, brain swelling and histology in pigs.

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes·2011
Same author

The effect of a gap-junction blocker, carbenoxolone, on ischemic brain injury and cortical spreading depression.

Neuroscience·2011
Same journal

Current Options for Kidney Protection: Are Renin-Angiotensin System Inhibitors Still Relevant?

Seminars in nephrology·2026
Same journal

Proposed Role for Quantitative Podocyturia as a Clinical Marker of Systemic Endothelial Injury: Implications for Cardiovascular Disease and Longevity.

Seminars in nephrology·2026
Same journal

Kidney Protection Options in 2025: Are Renin-Angiotensin System Inhibitors Still Needed?

Seminars in nephrology·2026
Same journal

From Nephron Number to Global Health.

Seminars in nephrology·2026
Same journal

Chronic Kidney Disease Progression Mechanisms: Why They Matter in an Era of Novel Kidney Protective Therapies.

Seminars in nephrology·2026
Same journal

Of Diuretics, Transporters, and Mechanisms of Hypertension.

Seminars in nephrology·2026
See all related articles

Area of Science:

  • Neuroscience
  • Pathology

Background:

  • Brain edema is characterized by intracellular or extracellular fluid accumulation.
  • Two main types are cytotoxic and vasogenic edema, each with distinct causes and mechanisms.

Purpose of the Study:

  • To differentiate the pathogenetic mechanisms of intracellular (cytotoxic) and extracellular (vasogenic) brain edema.
  • To elucidate the cellular and molecular underpinnings of these edema types.

Main Methods:

  • Review and synthesis of existing literature on brain edema pathogenesis.
  • Analysis of mechanisms involving ion transport, energy metabolism, and blood-brain barrier integrity.

Main Results:

  • Cytotoxic edema arises from energy failure impacting Na/K-ATPase, increased Na+ permeability, or Na+-driven pumps in astroglia.

Related Experiment Videos

  • Vasogenic edema results from blood-brain barrier damage, including tight junction opening or immature blood vessel sprouting.

    • Conclusions:

    • Understanding the distinct mechanisms of cytotoxic and vasogenic edema is crucial for targeted therapeutic strategies.
    • Pathogenesis involves energy-dependent ion transport for cytotoxic edema and barrier dysfunction for vasogenic edema.