[Some adhesion molecules in blood of patients with chronic B-cell lymphocytic leukemia]

Adhesion molecules actively participate in all stages of leukocyte migration, directly or indirectly by means of appropriate ligands. Therefore the aim of study was the determination of concentrations of L-selectin and ICAM-1 in cell culture supernatante, broken lymphocyte and plasma. The measurement of cell adhesion molecules (CA) concentrations were performed by means of immunoenzymatic kits of ELISA type in the patients with chronic lymphocytic leukaemia in the clinicals stages I and III. The levels of L-selectin were increased in cell culture supernatante but in the plasma concentrations of L-selectin were decreased. The behaviour of concentrations of studied substances in the broken lymphocytes was differently. It is possible that these investigations may appear useful in the future as an additional diagnostic indecks.