Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Ovarian Leydig cell tumor].

S Vujović1, Z Penezić, M Drezgić

  • 1Institut za endokrinologiju, dijabetes i bolesti metabolizma, Klinicki centar Srbije, Beograd, Medicinski fakultet Univerziteta u Beogradu.

Medicinski Pregled
|April 26, 2001
PubMed
Summary

Leydig cell tumors are rare ovarian neoplasms producing excess testosterone, causing virilization symptoms. Surgical removal is the only effective treatment, leading to symptom resolution and hormone normalization.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Depression: another cortisol-related comorbidity in patients with adrenal incidentalomas and (possible) autonomous cortisol secretion.

Journal of endocrinological investigation·2021
Same author

Premature ovarian insufficiency: an International Menopause Society White Paper.

Climacteric : the journal of the International Menopause Society·2020
Same author

Microsatellite variation of ESR1, ESR2, and AR in Serbian women with primary ovarian insufficiency.

Climacteric : the journal of the International Menopause Society·2018
Same author

Bone mineral density at different sites and vertebral fractures in Serbian postmenopausal women.

Climacteric : the journal of the International Menopause Society·2016
Same author

Cross-talk between muscle and bone in postmenopausal women with hypovitaminosis D.

Climacteric : the journal of the International Menopause Society·2016
Same author

Cancerous leptomeningitis and familial congenital hypopituitarism.

Endocrine·2016

Area of Science:

  • Gynecologic Oncology
  • Reproductive Endocrinology
  • Oncopathology

Background:

  • Leydig cell tumors are rare sex cord-stromal ovarian neoplasms, accounting for <0.6% of ovarian tumors.
  • These tumors are characterized by excessive sexual steroid production, primarily testosterone.
  • They predominantly affect women around age 28.

Observation:

  • Tumors are typically solid, yellowish, and nodular, measuring <5 cm.
  • Histopathology reveals polygonal Leydig cells with eosinophilic cytoplasm, lipid vacuoles, and pleomorphic nuclei.
  • Associated hyperthecosis may be present around the tumor.

Findings:

  • Clinical presentation includes signs of hyperandrogenism such as hirsutism, clitoromegaly, and menstrual irregularities.
  • Hormonal analysis shows elevated testosterone, androstenedione, and 17 OH progesterone, with suppressed gonadotropins.

Related Experiment Videos

  • Diagnostic imaging includes ultrasonography, MRI, and Doppler sonography; hCG stimulation tests confirm testosterone production.

    • Implications:

    • Surgical tumor excision is the definitive therapy for Leydig cell tumors.
    • Post-operative normalization of testosterone levels and gonadotropins is expected.
    • Complete resolution of clinical symptoms and signs follows successful surgical intervention.